Thyroid function

The thyroid gland is responsible for the synthesis of thyroxine (T4) and triiodthyronine (T3), with T3 being the more active substance.  Physiologically T3 is produced in the target cells by metabolizing T4. Inside the cell T3 specifically binds to a DNA regulating protein thereby controlling gene expression. Essentially the hormones of the thyroid gland increase the metabolic rate.Like other signal molecules T3 and T4 are controlled by many complex feedback mechanisms involving pituitary gland and hypothalamus. For the production of T3 and T4 the thyroid gland needs iodine and an enzyme called thyreoperoxidase. Looking at the diagnostic of functional disorders of this endocrine gland we find T3, T4 and TSH as well as the antibodies TRAb (TSH-Receptor-Ab), Tg-Ab (Thyreoglobulin-Ab) and TPO (Thyreoperoxidase-Ab, formerly known as MAK) to play a central role. Inflammation, autoimmune diseases and tumors can cause hyper- or hypothyreosis with severe clinical symptoms.

Product

Ordering number

Tests

Sample type

Incubation

Free T3

ELISA

AMP 90-E7100

96

S

2 h, 25 min

RIA CT

AMP 90-R7100

100

S

2 h

Free T4

ELISA

AMP 90-E7200

96

S

2 h, 30 min

RIA CT

AMP 90-R7200

100

S

2 h

T3

ELISA

AMP 90-E3100

96

S

1 h, 20 min

RIA CT

AMP 90-R3100

96

S

1 h

T4

ELISA

AMP 90-E3200

96

S

1 h, 20 min

RIA CT

AMP 90-R3200

96

S, P

1 h

Thyroglobulin (TG)

RIA

Selco Tg1 step AMP 90-R1301

100

S

overnight

RIA

Selco Tg AMP 90-R1300

100

S

overnight

Thyroglobulin Ab (TG Ab)

ELISA

AMP 20-E17100

96

S, P

1 h, 1 h, 15 min

RIA CT

Selco anti-TG AMP 90-R1540

100

S

90 min

Thyroglobulin Antigen

ELISA

AMP 90-E51500

96

S

1 h, 1 h, 15 min

Thyroid Microsomal Ab (TM Ab)

IRMA

AMP 90-R51700

100

on request

1 h, 2 h

Thyroid Peroxidase Ab (TPO Ab)

ELISA

Anti-TPO AMP 90-E3002

96

S

1 h, 30 min, 15 min

RIA

Anti-TPO AMP 90-R1500

100

S

90 min

TSH

ELISA

AMP 90-E3700

96

S

10 min, 90 min, 20 min

IRMA

AMP 90-R3700

96

S, P

2 h

TSH, Neonatal

ELISA

AMP 90-E52000

192

blood spot

overnight, 1 h, 15 min

IRMA

AMP 90-R52000

100

blood spot

Overnight

TSH, Utrasensitiv

ELISA

AMP 90-E51900

96

S

2 h, 20 min

T3-Uptake

ELISA

AMP 90-E51400

192

on request

1 h, 30 min