Human Papilloma Viruses

Cervical cancer (CC) is one of the most widely spread oncological diseases. Each year about 600,000 new CC cases are registered worldwide with more than 250,000 lethal outcomes. The virus nature of this cancer was confirmed by the World Health Organization and Human Papilloma Virus (HPV) is detected practically in 100 percent of cases of cervical precancer and cancer. Based on the frequency of detection of HPV genotypes in different grades of Cervical Intraepithelial Neoplasia (CIN Grades I – III), HPV genotypes are subdivided into High-risk HPV types (16, 18, 31 and 45), Intermediate-risk types (33, 35, 39, 51, 52, 56, 58, 59, and 68), and Low-risk types (6, 11, 42-44). Owing to the fact that cervical cancer has a long development period and a fail-safe recognizable preclinic phase, there’s a possibility to detect and prevent the disease on an early stage.

Kits for typing low and high carcinogenic risk HPV genotypes

V10/14-50/FRT

 

HPV Low & High Risk Typing Real-TM

Real Time Amplification kit

R

CE

55

1 х103 copies/ml

Kits for screening high carcinogenic risk HPV genotypes

The HPV High Risk Screen Real-TM Quant kitis an in vitro real-time amplification test for quantitative detection of 12 types of HPV (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59). It is known, that the level of viral load has a prognostic value and a viral load less than 105 HPV genomic equivalents in the swab or 103 genomic equivalents for 105 cells is considered insignificant and indicates the presence of transitory infection. A viral load of more than 105 genomic equivalents for 105 cells is considered to be highly significant and indicates the existence of dysplastic changes or high risk of their occurrence. Quantitative detection of viral load allows to evaluate the character and the stage of the infection.

HPV High Risk Screening kits

V31-100FRT

SA, RG, iQ, MX, A, B

HPV 14 Screening & 16, 18, 45 Typing Real-TM Quant

Complete Real Time Test with DNA-Sorb-A extraction kit

R

CE

100

5 х102 copies/ml

V31-100/2FRT

SA, RG, iQ, MX, A, B

HPV High Risk Screen Real-TM Quant

Real Time Amplification kit

R

CE

100

5 х102 copies/ml

TV31-100/2FRT 2X

SA, RG, iQ, SC, MX, A,IL,B

HPV High Risk Screen Real-TM 2X Quant (2 channels)

Complete Real Time Test with DNA-Sorb-A extraction kit

R

CE

100

5 х102 copies/ml

V31-100/2FRT 2X

SA, RG, iQ, SC, MX, A,IL,B

HPV High Risk Screen Real-TM 2X Quant (2 channels)

Real Time Amplification kit

R

CE

100

5 х102 copies/ml

V-26-50F

HPV High Risk Screen

A

CE

55

1 х103 copies/ml

Kits for typing high carcinogenic risk HPV genotypes

The new HPV Genotypes 14 Real-TM kit is an in vitro multiplex real -time amplification test for qualitative detection and genotyping of up to 14 genotypes of Human Papillomavirus (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68) in urogenital swabs and biopsies. The HPV Genotypes 14 Real-TM kit is based on two major processes: isolation of DNA from specimens and multiplex real-time amplification of 4 tubes for each sample. The test uses primers directed against regions of HPV types and β-globine gene as Internal Control. If the swab is not correctly prepared (high quantity of mucous or insufficient quantity of epithelial cells) the Internal Control will not be detected.

HPV High Risk Typing kits

V67-100FRT

SA, RG, MX,iQ,A, IL, B

 

HPV genotypes 14 Real-TM Quant NEW

Real Time Amplification kit for detection and quantification of high risk genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68

R

CE

100

5 х102 copies/ml

TV12-100FRT

SA, RG, SC,MX,iQ,A, IL,B

HPV 16/18 Real-TM Quant

Complete Real Time Test with DNA-Sorb-A extraction kit

R

CE

100

5 х102 copies/ml

V12-100FRT

SA, RG, iQ, SC, MX, A,IL,B

HPV 16/18 Real-TM Quant

Real Time Amplification kit

R

CE

100

5 х102 copies/ml

V-25-50F

HPV High Risk Typing

A

CE

55

1 х103 copies/ml

V-12-100R

Human Papillomavirus 16/18

A

CE

110

5 х102 copies/ml

Low carcinogenic risk

A group of low carcinogenic risk HPVis represented by more than 12 genotypes and they are called “low risk” because they cannot cause cervical cancer. Sometimes low-risk HPV types can cause genital warts. Genital warts are growths or bumps in the genital areas of men and women. They usually are painless and may be raised, flat, small or large, single or multiple. Among low risk HPV the genotypes 6 and 11 are of greatest importance as they are responsible for the overwhelming amount of low carcinogenic pointed condylomas of genital organs and for more than 90 percent of cases of condylomatosis of the larynx in children.

HPV Low Risk Typing kits

TV11-100FRT

SA, RG, iQ, SC, MX, A,IL,B

HPV 6/11 Real-TM

Complete Real Time Test with DNA-Sorb-A extraction kit

R

CE

100

5 х102 copies/ml

V11-100FRT

SA, RG, iQ, SC, MX, A,IL,B

HPV 6/11 Real-TM

Real Time Amplification kit

R

CE

100

5 х102 copies/ml

V-11-50F

HPV 6/11

A

CE

55

5 х102 copies/ml